Pyrrolizidine alkaloid (PA) containing plants primarily cause hepatotoxicity and liver failure in horses but may also cause respiratory disease (equine Jaagsiekte) depending on the plants implicated. The three PA containing plant families involved with poisoning in horses include
· Asteraceae (Senecio spp, tansy ragwort).
· Tobaceae (Crotalaria spp, rattlebox).
· Boraginaceae (Heliotropum, Amsinckia, Trichodesma and Echium spp).
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South African Veterinary Council (SAVC)
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Pyrrolizidine Alkaloid Poisoning in Horses